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50% glucose injection

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50% glucose injection
50% glucose injection
50% glucose injection
50% glucose injection
Detail

The main component of this product is glucose, and its chemical name is: D-(+)-glucopyranose-hydrate.

Molecular formula: C6H12O6•H2O

Molecular weight: 198.17

Excipient name: hydrochloric acid, water for injection.

【Properties】

This product is a colorless or almost colorless clear liquid; it has a sweet taste.

【Indications】

1. Replenish energy and body fluids; used for inadequate eating or a large amount of body fluid loss (such as vomiting, diarrhea, etc.) caused by various reasons, total intravenous nutrition, starvation ketosis;

2. Hypoglycemia;

3. Hyperkalemia;

4. Tissue dehydrating agent;

5. Prepare peritoneal dialysate;

6. Drug diluent;

7. Intravenous glucose tolerance test.

【Dosage】

1. Supplementary heat energy: When the patient's eating is reduced or unable to eat due to some reasons, 25% glucose injection can be given intravenously and body fluids can be supplemented at the same time. The amount of glucose is calculated based on the required heat energy.

2. Total intravenous nutrition therapy: glucose is the most important energy supply substance for this therapy. In non-protein heat energy, the ratio of energy supplied by glucose to fat is 2:1. The specific dosage depends on the clinical caloric needs. According to the needs of the amount of rehydration, glucose can be formulated into different concentrations from 25% to 50%. If necessary, insulin is added, and 1 unit of regular insulin is added for every 5-10g of glucose. As the normal application of hypertonic glucose solution is more irritating to the veins and requires the infusion of fat emulsion, large intravenous drip is generally used.

3. Hypoglycemia: In severe cases, 20-40ml of 50% glucose injection can be injected intravenously.

4. Starvation ketosis: In severe cases, 5-25% glucose injection should be used intravenously. 100g glucose per day can basically control the condition.

5. Hyperkalemia: 10-25% injection, plus 1 unit of regular insulin infusion for every 2-4g glucose, can reduce serum potassium concentration. However, this therapy only allows extracellular potassium ions to enter the cell, and the total potassium content in the body remains unchanged. If you do not take measures to excrete potassium, there is still the possibility of hyperkalemia again.

6. Tissue dehydration: Hypertonic solution (usually 50% glucose injection) is injected intravenously with 20-50ml. But the effect is short-lived. Clinically, attention should be paid to prevent hyperglycemia, and it is rarely used at present. When used to adjust the osmotic pressure of the peritoneal dialysate, 20ml of 50% glucose injection, that is, 10g glucose, can increase the osmotic pressure of 1L of peritoneal dialysate by 55mOsm/kgH2O.

【Adverse reactions】

1. Phlebitis. If you use a large vein drip, the incidence of phlebitis will decrease.

2. Extravasation can cause local swelling and pain.

3. Reactive hypoglycemia: combined with excessive use of insulin, the original tendency to hypoglycemia and the sudden stop of total intravenous nutrition therapy are likely to occur.

4. Hyperglycemia nonketotic coma: It is more common in diabetes, stress state, use of a large amount of corticosteroids, uremic peritoneal dialysis patients given hypertonic glucose solution and total nutrition therapy in the abdominal cavity.

5. Electrolyte disorders: Hypokalemia, hyponatremia and hypophosphatemia are prone to occur when simply supplementing glucose for a long time.

6. Excessive or excessive fluid supplementation in patients with original cardiac insufficiency, children and the elderly can cause palpitations, arrhythmia, and even acute left heart failure.

【Taboo】

1. Those who have not controlled diabetic ketoacidosis;

2. Non-ketotic hypertonic state of hyperglycemia.

【Precautions】

1. Excessive glucose injection during childbirth can stimulate fetal insulin secretion and cause hypoglycemia in the baby after delivery.

2. Use with caution in the following situations:

① Most gastrectomy patients are prone to dumping syndrome and hypoglycemia during oral glucose tolerance test, and should be changed to intravenous glucose test;

②Patients with periodic paralysis and hypokalemia;

③It is easy to induce hyperglycemia in stress state or application of glucocorticoid;

④ Patients with edema, severe heart and kidney insufficiency, ascites due to cirrhosis may easily cause water retention, so the infusion volume should be controlled; for patients with cardiac insufficiency, the drip rate should be controlled especially.

[Medicine for pregnant and lactating women]

Injecting too much glucose during delivery can stimulate fetal insulin secretion and cause hypoglycemia in the baby after delivery.

【Children's Medication】

Too fast or too much fluid can cause palpitations, arrhythmia, and even acute left heart failure.

【Geriatric Medication】

Too fast or too much fluid can cause palpitations, arrhythmia, and even acute left heart failure.

【medicine interactions】

uncertain.

【Overdose】

 uncertain.

【Pharmacology and Toxicology】

Glucose is one of the main heat sources of the human body. Each 1 gram of glucose can produce 4 calories (16.7KJ) of heat energy, so it is used to supplement heat. Treat hypoglycemia. When glucose and insulin are intravenously infused together, potassium ions are required for the synthesis of glycogen, so that potassium ions enter the cells and the blood potassium concentration decreases, so it is used to treat hyperkalemia. Hypertonic glucose injection can be used as a tissue dehydrating agent because of rapid intravenous bolus injection. In addition, glucose is the main substance that maintains and regulates the osmotic pressure of peritoneal dialysate.

【Pharmacokinetics】

Intravenous glucose directly enters the blood circulation. Glucose is completely oxidized in the body to produce CO2 and water, which are excreted from the body through the lungs and kidneys, and at the same time produce energy. Can also be converted into glycogen and fat storage. Generally, the ability of a normal human body to utilize glucose per minute is 6 mg/kg.




Personnel department: 0859-3338239

Email: tdyy@gztiandi.com

Address: Qianxinan Buyi and Miao Autonomous Prefecture, Guizhou Province No.6, Baokang Road, Yilong Hongxing Pharmaceutical Industrial Park

@copyright 2017 Guizhou Tiandi Pharmaceutical Co., Ltd.

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